Dexamethasone cyclophosphamid pulse therapy in pemphigus-appraisal of its outcome
نویسندگان
چکیده
منابع مشابه
Dexamethasone-cyclophosphamide pulse therapy in pemphigus.
Fifty patients with pemphigus (45 pemphigus vulgaris, 5 pemphigus foliaceus) were treated with dexamethasone-cyclophosphamide pulse therapy. The pulse consisted of 136 mg dexamethasone dissolved in 5% dextrose given in a drip over a period of 1-2 hours on 3 consecutive days. In addition, 500 mg cyclophosphamide was added in the drip on the first day. Such pulses were given at monthly intervals....
متن کاملRandomized controlled trial of adjuvant oral dexamethasone pulse therapy in pemphigus vulgaris: PEMPULS trial.
OBJECTIVE To determine the therapeutic effect of adjuvant dexamethasone pulse therapy when given in addition to conventional treatment of pemphigus vulgaris. DESIGN A randomized, placebo-controlled trial. SETTING International European, multicenter outpatient and inpatient study. PATIENTS Of the 20 enrolled patients, 11 were randomized to the dexamethasone pulse (DP) group and 9 to the pl...
متن کاملPulse intravenous cyclophosphamide therapy in pemphigus.
BACKGROUND Adjuvant therapy is commonly used in pemphigus to mitigate the high morbidity and mortality associated with the use of corticosteroids and improve disease control. However, these adjuvant agents are not without adverse effects of their own, including an increased risk of malignancy with the use of oral immunosuppressives. Intravenous pulse cyclophosphamide, which may be more efficaci...
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In this study, five cases of pemphigus vulgaris and two cases of pemphigus foliaceus were treated with cyclophosphamide pulse therapy associated with prednisone, resulting in the need for a smaller maintenance dose of prednisone. In three cases of pemphigus vulgaris and one case of pemphigus foliaceus, dexamethasone and cyclophosphamide pulse therapy associated with prednisone helped the lesion...
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BACKGROUND Although corticosteroids have dramatically altered the prognosis of patients with pemphigus vulgaris, morbidity and mortality from systemic corticosteroid side-effects remains high. High-dose intravenous methylprednisolone has been used successfully in blistering diseases to avoid the complications of long-term orally-administered glucocorticoids. The objective of this study was to c...
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ژورنال
عنوان ژورنال: Indian Dermatology Online Journal
سال: 2012
ISSN: 2229-5178
DOI: 10.4103/2229-5178.98202